Zincovit Drop Reduces Oxidative Stress Induced by Carbon Tetrachloride in Rats
نویسندگان
چکیده
Zincovit drop is a combined formulation of multivitamins-minerals, flax seed oil and lysine. This study has focused on the in vivo antioxidant potential of Zincovit drop against carbon tetrachloride induced oxidative stress in rats. Rats divided into six groups containing six rats in each group. Zincovit drop at the dose of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day was investigated in carbon tetrachloride intoxicated rats. Biochemical analysis of malondialdehyde, glutathione-S-transferase and catalase in liver tissue was performed. Oral treatment with Zincovit drop mostly at all the three doses 25, 50 and 100 mg/kg/day for 7 days reversed CCl4induced alterations in malondialdehyde (p<0.01), glutathione-S(p<0.001) and catalase (p<0.05) compared to carbon tetrachloride intoxicated control (untreated) animals. The present study demonstrated that Zincovit drop may be of great importance in oxidative stress associated diseases as nutritional food supplement.
منابع مشابه
Effect of Human Mesenchymal Stem Cell-Conditioned Medium Injection on Oxidative Stress Induced by Carbon Tetrachloride in the Liver Tissue of Rats
Background: Carbon tetrachloride (CCI4) is used as a chemical intermediate in industries. It can be converted into toxic reactive products of trichloromethyl radical under the influence of cytochrome P450 enzymes, and cause tissue damage, including liver damage, through oxidative stress. Liver transplantation is an effective treatment for liver failure but is limited due to the shortage of orga...
متن کاملCan crocin play a preventive role in Wistar rats with carbon tetrachloride-induced nephrotoxicity?
Objective(s): To investigate protective role of crocin by attempting to create nephrotoxicity with carbon tetrachloride.Materials and Methods: Ethics committee approval was obtained and 50 male Wistar rats were randomly divided into 5 groups that included 10 rats each: Control, Corn oil, Crocin, Carbon tetrachloride (CCl4), and Crocin + Carbon tetrachloride. Following the experiments, the rats ...
متن کاملThe Effects of Silymarin on Oxidative Status and Bone Characteristics in Japanese Quail Subjected to Oxidative Stress Induced by Carbon Tetrachloride
This experiment was conducted to assess the effects of Silymarin on oxidative status, bone characteristics, and some blood parameters in Japanese quail subjected to oxidative stress induced by carbon tetrachloride (CCl4). The experiment was performed as a completely randomized design with four replicates, each with 30 birds, using a 2 × 2 factorial arrangement with two doses of Silymarin (0 and...
متن کاملEffects of Silymarin on Growth Performance, Internal Organs and Some Blood Parameters in Japanese Quail Subjected to Oxidative Stress Induced by Carbon Tetrachloride
The effects of Silymarin on growth performance, internal organs, and some blood parameters were investigated in Japanese quail that were subjected to oxidative stress induced by carbon tetrachloride (CCl4). An experiment was conducted as a completely randomized design in a factorial arrangement (2 × 2) with four replicates of 30 birds each. Factors included two levels of Silymarin (0 and 1 mL/k...
متن کاملThe protective effect of Liza klunzingeri protein hydrolysate on carbon tetrachloride-induced oxidative stress and toxicity in male rats
Objective(s): Today, consumers are looking for food products providing health benefits in addition to meeting the basic nutritional needs of the body. This study aimed to evaluate the antioxidant and cytotoxic effects of Liza klunzingeri protein hydrolysate both in vivo and in vitro.Materials and Methods: Fish protein hydrolysate (FPH) w...
متن کامل